Cardiotonic steroids
نویسندگان
چکیده
منابع مشابه
Cardiotonic Steroids and Cardiac Fibrosis
It is well known and has been shown that patients who have chronic renal failure tend to develop and die of cardiac causes. These patients are known to develop a cardiomyopathy that is characterized by left ventricular hypertrophy and significant diastolic dysfunction. It has also been shown that the chronic renal failure condition is characterized by significant sodium pump inhibition due to i...
متن کاملCardiotonic Steroids as Modulators of Neuroinflammation
Cardiotonic steroids (CTS) are a class of specific ligands of the Na(+), K(+)- ATPase (NKA). NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gradient through active transport, NKA can also act as a signal transducer in the presence of CTS. Inflammation, in addition to importantly driving organism def...
متن کاملA Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues
A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine derivatives.
متن کاملCardiotonic steroids on the road to anti-cancer therapy.
The sodium pump, Na(+)/K(+)-ATPase, could be an important target for the development of anti-cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion and its aberrant expression and activity are implicated in the development and progression of different cancers. Cardiotonic steroids, known ligands of the sodium pump have been widely used for the treatment ...
متن کاملMTD approach to quantitative structure-activity relationships for cardiotonic steroids.
A minimal topological difference (MTD) approach is made to describe quantitative structure-activity relationships (QSAR) for the Na+, K+-ATPase inhibitory activity of cardiotonic steroids. The calculations take into account 20 derivatives of digitoxigenin, digoxigenin, and gitoxigenin with small substituents at different sites of the steroid backbone. A multiple correlation coefficient of r = 0...
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ژورنال
عنوان ژورنال: Chemistry of Natural Compounds
سال: 2009
ISSN: 0009-3130,1573-8388
DOI: 10.1007/s10600-009-9384-0